Guo Laboratory
Department of Neuroscience  |  Yale School of Medicine

Latest News

First manuscript of the lab has been posted on bioRxiv.

Dr. Lian-Huan Wei joins the lab. She received her Ph.D. from Peking University, where she studied the functions of RNA m6A methylation in plants. Welcome, Dr. Wei!

Dr. Guo has received an NIH Director's New Innovator (DP2) Award for studying disease-associated repeat RNAs:

Congratulations to Aziz Eshov for winning a poster award at the Yale RNA Center annual retreat!

RNA regulation in health and diseases of the Nervous System
We are fascinated by the numerous questions at the intersection of neuroscience and RNA biology.  
Currently, we are investigating the roles of RNA metabolism in neuronal development, homeostasis, and neurological diseases, taking a combination of computational, biochemical, genetic, and genomic approaches.​

RNA repeats
Localization of neuronal mRNAs
Noncoding RNA
A variety of neurological disorders, including  amyotrophic lateral sclerosis and frontotemporal dementia, are caused by the expansion of nucleotide repeats in the genome. Once transcribed, the RNA repeats exhibit distinctive properties. For example, some repeats undergo phase seperation and form distinct foci. Some are translated into toxic polypeptides via a noncanonical mechanism. We aim to determine the causes of these distinctive properties and their pathophysiological roles, with the goal of developing novel  therapeutics.
  Spatially precise regulation of gene expression is critical for morphologically complex cells. In neurons, this is achieved in part through the localization of mRNAs to distal compartments in dendrites and axons. Accumulating evidence suggests that mRNA localization and local translation play important roles in neuronal development and plasticity.  We aim to systematically identify the cis-regulatory elements (often being secondary structures) in mRNAs that determine their localization as well as the proteins that mediate their functions.
Since the advent of high-throughput DNA sequencing technologies, the identification of the cellular repertoire of noncoding RNAs has vastly outpaced our understanding of their biological functions. Of the many thousands of small RNAs and long noncoding RNAs in cells, only a small fraction has been functionally characterized. We are interested in developing new tools to interrogate their functions during development of the mammalian nervous system.
Join Us
We aspire to create a diverse, stimulating, and collaborative lab environment. Motivated scientists of all stages and all backgrounds are welcome to join our growing team!
Graduate students are recruited through the Yale Biological and Biomedical Sciences (BBS) program.
Our lab is affiliated with Interdepartmental Neuroscience Program (INP) , Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) and ​ Molecular Cell Biology, Genetics, and Development (MCGD)  tracks.  

Please contact Junjie to discuss current rotation projects.
Postdoctoral positions are currently available. Start date is flexible. Candidates should have received a doctoral degree no more than 2 years before the start date. Researchers with a passion in RNA biology and neuroscience, regardless of their training background, are welcome to apply.  Expertise in any of the following areas is highly valued though not required:

  • Animal genetics (any model organism)
  • High-throughput genetic screens
  • iPSC-based disease modeling
  • Transcriptomic and proteomic analysis  

Please email your application to Junjie, including:

  • A cover letter describing your past training, research interests and career goals
  • A detailed CV
  • Contact information of referees

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